Fr. Anscar Chupungco became rector-president from 2001, San Beda’s centenary, to 2007. This was also the year that San Beda was granted the five-year full autonomy and administrative deregulation by the Commission on Higher Education. More undergraduate degree programs were offered in the College of Arts and Sciences, where females were accepted beginning in 2003.
In 2001, the Graduate School of Business opened, and the College of Law received the Model Law Library Award given by the Supreme Court. The red toga was adopted in 2002. A new Athlete’s Quarters and the St. Joseph Physical Plant Building were constructed.
The Graduate School of Liturgy and the College of Medicine were established in 2002; the College of Nursing in 2003; the Graduate School of Law in 2004.
The Graduate School of Liturgy alumni have been appointed directors of liturgy in their dioceses. Existing diocesan directors, sisters and lay leaders have also sought further studies in the school.
The College of Medicine graduates first exceeded the national licensure exams average rating in February 2012 with an 84% rating for first time takers. By 2013, overall rating, including irregulars hit 89% in2013 when Marie Angelie So placed fourth in the licensure exams. In 2014, Grace Arviola earned third place and the first time takers’ ratings breached the 90% mark. The student population crossed the 600 mark in 2012.

The College of Nursing was rated third best in the country during the December 2005 board exams when Pearl Austria Martinez earned the eighth highest mark. It has consistently exceeded the national passing average and obtained a class passing mark of 100% in 2016, ’17, ’18. So far, five graduates have landed in the top ten places in the licensure exams.
The Integrated Basic Education (Grade School and High School) were transferred in 2004 to Taytay, Rizal, where girls were accepted. The first doctoral degree, Doctor of Liturgy was conferred in 2006. In 2007, the San Beda College Museum was inaugurated.
St. Placid Sports Center, the training den of the fabled Red Lions basketball team, was constructed in 2002 then repaired and renovated in 2010. Co-named as the Don Luis Go Sy Memorial Center, it houses the Robert Coyiuto, Jr. Gymnasium and the Manuel V. Pangilinan Gymnasium.
The Montserrat Center for Religious Formation was inaugurated in December 2011 to better serve the need of the Bedans of Manila, Rizal, and Muntinlupa for spiritual retreats.
A sculpture of St. Benedict created by National Artist Napoleon Abueva was installed at the Jubilee garden in 2008 and one of St. Bede by Dionas Roces was installed in 2018.